Response-adaptive dose-finding under model uncertainty
نویسندگان
چکیده
منابع مشابه
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When modeling a dose-response for a drug based on bivariate binary data such as two co-primary efficacy endpoints in early stages of development, there is usually uncertainty about the from of the true underlying dose-response shape. Often, investigators fit several different models that are deemed plausible, but later fail to acknowledge this uncertainty in inference that is based on a single ...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2011
ISSN: 1932-6157
DOI: 10.1214/10-aoas445